Id 1 and Id 3 expression is associated with increasing grade of prostate cancer: Id 3 preferentially regulates CDKN 1B
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چکیده
منابع مشابه
Id1 and Id3 expression is associated with increasing grade of prostate cancer: Id3 preferentially regulates CDKN1B
As transcriptional regulators of basic helix-oop-helix (bHLH) transcription and non-bHLH factors, the inhibitor of differentiation (Id1, Id2, Id3, and Id4) proteins play a critical role in coordinated regulation of cell growth, differentiation, tumorigenesis, and angiogenesis. Id1 regulates prostate cancer (PCa) cell proliferation, apoptosis, and androgen independence, but its clinical signific...
متن کاملId-1 and Id-2 proteins as molecular markers for human prostate cancer progression.
PURPOSE Id proteins are dominant-negative regulators of basic helix-loop-helix transcription factors that control malignant cell behavior in many different tissues. This study aimed to identify the potential role of Id-1 and Id-2 proteins as molecular makers for prostate cancer progression. EXPERIMENTAL DESIGN Using the technique of immunohistochemistry, we determined Id-1 and Id-2 expression...
متن کاملProteasome mediated degradation of Id-1 is associated with TNFalpha-induced apoptosis in prostate cancer cells.
Overexpression of the helix-loop-helix protein Id-1 has been reported in over 20 types of cancer. While a number of factors have been demonstrated to regulate Id-1 gene transcription, little is known about the mechanisms responsible for its degradation. In this study, we have demonstrated that Id-1 protein stability was regulated by TNFalpha in prostate cancer cells. We found that exposure of p...
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http://bloodjournal.hematologylibrary.org/content/110/7/2351.full.html Updated information and services can be found at: (166 articles) Stem Cells in Hematology (3094 articles) Hematopoiesis and Stem Cells Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing ...
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ژورنال
عنوان ژورنال: Cancer Medicine
سال: 2012
ISSN: 2045-7634,2045-7634
DOI: 10.1002/cam4.19